Today challenge in project management is related to provide benefits to the business ad lower costs possible and with less additional work possible for business team. The first point is to assess company maturity and according to that configure appropriately PMO processes and tailor PM methodologies; in doing that is fundamental obtain Executives support. As soon as processes are clearly defined and communicated, standards and template must be prepared to encourage business team to use that facilitating their work. It is also important track processes performance defining precisely KPIs and report them to Executive in order to give visibility to the ROI and better performance in PMO and related processes. PM is all create value to a company and consequently must be a ROI and released step-by-step and not with a big bang approach, selecting deliverables add more value to the business and create more confidence to supporters. An additional challenge today is the Agile methodology, which must be recognized for which project and context it adds really value and when it creates only bureaucracy. By definition PM is different for different contexts, so the project manager must have a strategic vision in how to adapt standards to his/her environment.